Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line

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• 作者：Hai Xuan Nguyen ; Mai Thanh Thi Nguyen ; Thy Anh Nguyen ; Nhi Y Thi Nguyen ; Dao Anh Thi Phan ; Phuoc Ho Thi ; Trong Huu Phan Nguyen ; Phu Hoang Dang ; Nhan Trung Nguyen ; Jun-ya Ueda ; Suresh Awale
• 关键词：Caesalpinia sappan ; Cleistanthane diterpene ; Antiausterity strategy ; Anticancer drug discovery ; PANC-1 ; Nutrient starvation
• 刊名：Fitoterapia
• 出版年：December, 2013
• 年：2013
• 卷：91
• 期：Complete
• 页码：148-153
• 全文大小：727 K

文摘

Three new cleistanthane diterpenes named tomocinon (1), tomocinol A (2), and tomocinol B (3), were isolated from the EtOAc extract of the seed of Caesalpinia sappan. Their structures were determined by extensive NMR spectroscopic analysis. The absolute stereochemistry of tomocinon (1) has been established by CD spectroscopic analysis. Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC₅₀ value of 34.7 渭M, 42.4 渭M and 39.4 渭M, respectively.