Salubrinal reduces oxidative stress, neuroinflammation and impulsive-like behavior in a rodent model of traumatic brain injury
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- 作者：Aric F. Logsdona ; b ; d ; 1 ; alogsdo1@mix.wvu.edu" class="auth_mail" title="E-mail the corresponding author ; Brandon P. Lucke-Woldb ; d ; 1 ; bwold@mix.wvu.edu" class="auth_mail" title="E-mail the corresponding author ; Linda Nguyena ; lnguyen1@mix.wvu.edu" class="auth_mail" title="E-mail the corresponding author ; Rae R. Matsumotoc ; rae.matsumoto@tu.edu" class="auth_mail" title="E-mail the corresponding author ; Ryan C. Turnerb ; d ; rcturner@hsc.wvu.edu" class="auth_mail" title="E-mail the corresponding author ; Charles L. Rosenb ; d ; crosen@hsc.wvu.edu" class="auth_mail" title="E-mail the corresponding author ; Jason D. Hubera ; b ; d ; jdhuber@hsc.wvu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：TBI ; traumatic brain injury ; sTBI ; single blast-induced traumatic brain injury ; rTBI ; repeated blast-induced traumatic brain injury ; ER ; endoplasmic reticulum ; SAL ; salubrinal ; GFAP ; Glial fibrillary acidic protein ; FJB ; Fluorojade B ; JNK ; c-jun N-terminal kinase ; NFκB ; nuclear factor kappa beta ; iNOS ; intrinsic nitric oxide synthase ; BiP ; binding immunoglobulin protein ; CHOP ; C/EBP homology protein ; TNFα ; tumor necrosis factor alpha ; IL-1β ; interleukin 1 beta ; NOX ; NADPH-oxidase
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1643
- 期：Complete
- 页码：140-151
- 全文大小：2340 K
文摘
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Blast injury induces secondary injury cascades and behavioral deficits.
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Endoplasmic reticulum stress and oxidative stress are associated with neuroinflammation.
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Secondary injury cascades are linked to neurobehavioral dysfunction after blast injury.
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Salubrinal targets secondary injury cascades to ameliorate neurodegenerative phenotype.
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Salubrinal prevents impulsive-like behavior following repetitive blast injury.