Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/progenitor cells into neurons
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- 作者：Jue Wanga ; b ; 1 ; Zhizhong Yec ; 1 ; Shuhui Zhenga ; Luming Chend ; Yong Wane ; Yubin Denga ; dengyub@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ruirui Yanga
- 关键词：NSC ; neural stem cell ; SCI ; spinal cord injury ; DAPT ; N-[N-(3 ; 5-difluorophenacetyl)-1-alanyl]-S-phenylglycinet-butylester ; NICD ; Notch intracellular domain ; DMSO ; dimethyl sulfoxide ; OMgp ; oligodendrocyte myelin glycoprotein ; GFP ; green fluorescent protein ; MAG ; myelin-associated glycoprotein ; Nogo A ; neurite outgrowth inhibitory A ; RhoA ; Ras homolog gene family ; member A ; GFAP ; glial fibrillary acidic protein ; CNPase ; Cyclic neucleotide phosphodiesterase ; NeuN ; Feminizing Locus on X-3 ; Fox-3
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：1634
- 期：Complete
- 页码：34-44
- 全文大小：7225 K
文摘
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Silencing Lingo-1 shRNA could promote the cells differentiate more into neurons.
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Blocking Notch signaling could promote the cells differentiate more into neurons.
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The stem/progenitor cells expressed more Lingo-1 after treated with DAPT.