Piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels via activation of alpha-secretase and matrix metalloproteinase-9
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- 作者：Boyoung Choia ; Suyeon Kima ; Bong-Geum Janga ; Min-Ju Kima ; b ; zolim@hallym.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; Aβ ; beta-amyloid ; APP ; amyloid precursor protein ; APPsw ; APP Swedish mutant ; NEP ; neprilysin or neutral endopeptidase ; IDE ; insulin degrading enzyme ; MMP-9 ; matrix metalloproteinase-9 ; HEK293 ; human embryonic kidney 293 ; CTF ; carboxyl terminal fragment ; sAPP ; soluble APP ; AICD ; APP intracellular domain ; NICD ; notch intracellular domain ; PARP ; poly (ADP-rebose) polymerase ; FL-APP ; full length APP ; Res ; resveratrol ; Oxy ; oxyresveratrol ; Pice ; piceatannol
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：23
- 期：Complete
- 页码：124-134
- 全文大小：1900 K
文摘
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Resveratrol, oxyresveratrol, and piceatannol induce apoptosis and autophagy at higher doses.
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Resveratrol, oxyresveratrol, and piceatannol decrease γ-secretase processing at higher doses.
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Piceatannol increases α-secretase processing and activates MMP-9 at lower doses.
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Piceatannol is the only resveratrol analogue that reduces Aβ levels without cytotoxicity.