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Extending the structure−activity relationship study of marine natural ningalin B analogues as P-glycoprotein inhibitors
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文摘
A series of novel ningalin B analogues were synthesized. A ring and its two methoxy groups are important pharmacophores. Compound 23 shows most potent P-gp modulator in reversing paclitaxel resistance. Compound 23 restores intracellular antitumor drug accumulation by inhibiting P-gp.

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