Elucidation of hypoglycemic action and toxicity studies of insulin-like protein from Costus igneus
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- 作者：Manasi R. Hardikara ; Mokshada E. Varmaa ; Anjali A. Kulkarnib ; Prasad P. Kulkarnia ; Bimba N. Joshia ; bimbajoshi@aripune.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：BCA ; bicinchoninic acid ; ILP ; insulin-like protein from Costus igneus ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s Medium ; FBS ; fetal bovine serum ; GLUT-4 ; glucose transporter-4 ; IR ; insulin receptor ; IRS-1 ; insulin receptor substrate-1 ; 2-NBDG ; [2-{N-(7-nitrobenz-2-oxa-1 ; 3-diazol-4-yl) amino}-2-deoxyglucose] ; PBS ; phosphate buffered saline ; STZ ; streptozotocin ; TNF-α ; tumor necrosis factor-α
- 刊名：Phytochemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：99-107
- 全文大小：2687 K
文摘
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Orally active ILP from Costus igneus acts via insulin signaling pathway.
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10">Insulin-like protein (ILP) did not show toxicity in normal and diabetic Swiss mice.
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15">ILP showed sequence homology with the predicted protein from Physcomitrella patens.