Ferriheme catalyzes nitric oxide reaction with glutathione to form S-nitrosoglutathione: A novel mechanism for formation of S-nitrosothiols

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• 作者：Enika Nagababu^a ; ^b ; ¹ ; ^{nenika1@JHMI.edu}
• 关键词：ECs ; endothelial cells ; GSH ; glutathione ; NO ; nitric oxide ; GSNO ; S-nitrosoglutathione ; RBCs ; red blood cells ; SNO ; S-nitrosothiols ; DMPO ; 5 ; 5-dimethyl-1-pyrroline N-oxide ; DTPA ; diethylenetriaminepentaacetic acid
• 刊名：Free Radical Biology and Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：101
• 期：Complete
• 页码：296-304
• 全文大小：1032 K
• 卷排序：101

文摘

An electron acceptor is a prerequisite to react NO with thiols to form S-nitrosothiols. Ferriheme is such an electron acceptor from GSH. NO reacts with ferriheme-GS complex and generates GSNO by a non-radical mechanism. NO reacts with ferriheme-GS faster than it is consumed by endothelial cells. Interaction between NO, GSH and ferriheme is a possible route for generation of GSNO in vivo.