Surface modification of PLGA nanoparticles to deliver nitric oxide to inhibit Escherichia coli growth

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• 作者：Nina A. Reger^a ; Wilson S. Meng^b ; Ellen S. Gawalt^a ; ^c ; ^{gawalte@duq.edu}
• 关键词：Nitric oxide ; Polymer nanoparticles ; PLGA ; PVA ; S-Nitrosocysteamine ; Escherichia coli
• 刊名：Applied Surface Science
• 出版年：2017
• 出版时间：15 April 2017
• 年：2017
• 卷：401
• 期：Complete
• 页码：162-171
• 全文大小：1937 K
• 卷排序：401

文摘

Thin film functionalized PLGA nanoparticles were modified to release nitric oxide from an s-nitrosothiol donor. The nitric oxide modified nanoparticles were bacteriostatic against Escherichia coli. The nitric oxide modified nanoparticles increased the effectiveness of tetracycline against Escherichia coli. The modified nitric oxide nanoparticles did not exhibit cytotoxic effects against fibroblasts.