Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease
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- 作者：Ludovico Arcuria ; b ; Riccardo Viaroc ; Simone Bidoa ; b ; Francesco Longoa ; b ; Mariangela Calcagnoa ; b ; Pierre-Olivier Fernagutd ; e ; Nurulain T. Zaverif ; Girolamo Calò ; a ; b ; Erwan Bezardd ; e ; Michele Moraria ; b ; m.morari@unife.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAV2/9 ; adeno-associated viral vector pseudotype2/9 ; DA ; dopamine ; hα-syn ; p.A53T human α-synuclein ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 5 ; 6-tetrahydropyridine ; N/OFQ ; nociceptin/orphanin FQ ; NOP ; N/OFQ peptide receptor ; 6-OHDA ; 6-hydroxydopamine ; p-α-syn ; phosphorylated α-synuclein ; PD ; Parkinson's disease ; ppN/OFQ ; N/OFQ precursor ; SNc ; substantia nigra compacta ; SNr ; substantia nigra reticulata ; TH ; tyrosine hydroxylase
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：89
- 期：Complete
- 页码：55-64
- 全文大小：1450 K
文摘
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Genetic deletion of NOP attenuates acute MPTP-induced dopamine cell loss in mice
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NOP receptor antagonism prevents subacute MPTP-induced dopamine cell loss in mice
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NOP receptor antagonism attenuates α-synuclein-induced dopamine cell loss in rats
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Endogenous N/OFQ contributes to dopamine cell loss in models of Parkinson's disease