Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Instability

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• 作者：Gerson Rothschild¹ ; Uttiya Basu¹ ; ^{ub2121@cumc.columbia.edu}
• 关键词：enhancer transcription ; enhancer RNA ; RNA exosome ; bidirectional transcription ; long noncoding RNA
• 刊名：Trends in Genetics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：33
• 期：2
• 页码：143-154
• 全文大小：2185 K
• 卷排序：33

文摘

Intergenic and intragenic enhancers found inside topologically associated regulatory domains (TADs) express noncoding RNAs, known as enhancer RNAs (eRNAs). Recent studies have indicated these eRNAs play a role in gene regulatory networks by controlling promoter and enhancer interactions and topology of higher-order chromatin structure. Misregulation of enhancer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA structures, noncoding RNA associated DNA/RNA hybrid formation, and promote collisions of transcription complexes with replisomes. It is revealing that many chromosomal aberrations, some associated with malignancies, are present inside enhancer and/or promoter sequences. Here, we expand on current concepts to discuss enhancer RNAs and enhancer transcription, and how enhancer transcription influences genomic organization and integrity.