Molecular characterization of insulin from squamate reptiles reveals sequence diversity and possible adaptive evolution
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- 作者：Genki Yamagishi ; Ayaka Yoshida ; Aya Kobayashi ; Min Kyun Park ; biopark@bs.s.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：aa ; amino acid(s) ; BEB ; Bayes Empirical Bayes ; bp ; base pair(s) ; cDNA ; DNA complementary to RNA ; dCTP ; cytidine 5&prime ; -triphosphate ; dN ; number of nonsynonymous substitutions ; dNTP ; deoxyribonucleoside 5&prime ; -triphosphate ; dS ; number of synonymous substitutions ; IGF ; insulin-like growth factor ; INS ; insulin gene ; LRT ; log likelihood ratio test ; mRNA ; messenger RNA ; ω ; non-synonymous-to-synonymous substitution ratio ; ORF ; open reading frame ; PCR ; polymerase chain reaction ; PSS ; positively sel
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：225
- 期：Complete
- 页码：197-211
- 全文大小：1989 K
文摘
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Insulin cDNAs were isolated from 27 squamate species.
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The deduced amino acid sequences showed high degree of variation.
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Substitutions were observed at sites with possible effect on biological functions.
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The estimated values of ω suggest unique evolutionary process among vertebrates.