Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes
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- 作者：Hisako Matsumoto ; MD ; PhD&lowast ; ; &dagger ; ; hmatsumo@kuhp.kyoto-u.ac.jp ; Yoshihiro Kanemitsu ; MD ; PhD&lowast ; ; &dagger ; ; Tadao Nagasaki ; MD ; PhD&lowast ; ; &dagger ; ; Yuji Tohda ; MD ; PhD&dagger ; ; &Dagger ; ; Takahiko Horiguchi ; MD ; PhD&dagger ; ; § ; ; Hideo Kita ; MD ; PhD&dagger ; ; || ; Kazunobu Kuwabara ; MD ; PhD&dagger ; ; § ; ; Keisuke Tomii ; MD ; PhD&dagger ; ; ¶ ; ; Kojiro Otsuka ; MD ; PhD&lowast ; ; &dagger ; ; ¶ ; ; Masaki Fujimura ; MD ; PhD&dagger ; ; # ; Noriyuki Ohkura ; MD ; PhD&dagger ; ; # ; Katsuyuki Tomita ; MD ; PhD&dagger ; ; &Dagger ; ; Akihito Yokoyama ; MD ; PhD&dagger ; ; &lowast ; &lowast ; ; Hiroshi Ohnishi ; MD ; PhD&dagger ; ; &lowast ; &lowast ; ; Yasutaka Nakano ; MD ; PhD&dagger ; ; &dagger ; &dagger ; ; Tetsuya Oguma ; MD ; PhD&dagger ; ; &dagger ; &dagger ; ; Soichiro Hozawa ; MD ; PhD&dagger ; ; &Dagger ; &Dagger ; ; Yumi Izuhara ; MD&lowast ; ; Isao Ito ; MD ; PhD&lowast ; ; Tsuyoshi Oguma ; MD ; PhD&lowast ; ; &dagger ; ; Hideki Inoue ; MD ; PhD&lowast ; ; Tomoko Tajiri ; MD ; PhD&lowast ; ; Toshiyuki Iwata ; MD ; PhD&lowast ; ; Junya Ono ; BS§ ; § ; ; Shoichiro Ohta ; MD ; PhD|||| ; Tomomitsu Hirota ; DDS ; PhD¶ ; ¶ ; ; Takahisa Kawaguchi ; MSc## ; Mayumi Tamari ; MD ; PhD¶ ; ¶ ; ; Tetsuji Yokoyama ; MD ; PhD&lowast ; &lowast ; &lowast ; ; Yasuharu Tabara ; PhD## ; Fumihiko Matsuda ; PhD## ; Kenji Izuhara ; MD ; PhD&dagger ; &dagger ; &dagger ; ; Akio Niimi ; MD ; PhD&lowast ; ; &dagger ; ; &Dagger ; &Dagger ; &Dagger ; ; Michiaki Mishima ; MD ; PhD&lowast ; ; &dagger ;
- 刊名：Annals of Allergy, Asthma & Immunology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：118
- 期：2
- 页码：197-203
- 全文大小：403 K
- 卷排序：118
文摘
Sensitization to Staphylococcus aureus enterotoxin (SE) is a known risk factor for asthma susceptibility and severity. However, how SE sensitization is involved in asthma, particularly nonatopic asthma and/or late-onset asthma, remains uncertain.ObjectiveTo clarify the involvement of SE sensitization in nonatopic and/or late-onset asthma and its association with a polymorphism of the cysteinyl leukotriene receptor 1 gene (CysLTR1), which was examined because CysLT signaling is closely associated with late-onset eosinophilic asthma.MethodsWe assessed associations between sensitization to SE (A and/or B) and clinical indexes in 224 patients with asthma (mean age, 62.3 years; 171 women) from a cohort of the Kinki Hokuriku Airway Disease Conference, particularly those with nonatopic asthma (not sensitized to common aeroallergens) and/or late-onset asthma. Associations between SE sensitization and CysLTR1 polymorphism (rs2806489), a potential regulatory variant for atopic predisposition in women, were also assessed in a sex-stratified manner.ResultsA total of 105 patients (47%) with asthma were sensitized to SE. Among patients with nonatopic asthma (n = 67) or with late-onset asthma (n = 124), those sensitized to SE had significantly higher serum total IgE and periostin levels than those not sensitized. In nonatopic patients, a rapid decrease in forced expiratory volume in 1 second was associated with SE sensitization. In women with asthma, rs2806489 was associated with sensitization to SEB and age at asthma onset.ConclusionSE sensitization contributes to TH2 inflammation in nonatopic and/or late-onset asthma. In women with asthma, the CysLTR1 variant might be associated with sensitization to SEB and age at asthma onset.