Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma
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- 作者：Syed A. Ali1 ; Verline Justilien1 ; Lee Jamieson1 ; Nicole R. Murray1 ; Alan P. Fields1 ; fields.alan@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：protein kinase Cι ; ELF3 ; NOTCH signaling ; KRAS-driven lung adenocarcinoma ; therapeutic intervention
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：14 March 2016
- 年：2016
- 卷：29
- 期：3
- 页码：367-378
- 全文大小：3862 K
文摘
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PKCι maintains a tumor-initiating cell phenotype in KRAS LADC
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PKCι phosphorylates and recruits ELF3 to the NOTCH3 promoter
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PKCι-ELF3-NOTCH3 signaling drives LADC tumor formation
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Combined PKCι and NOTCH blockade synergistically inhibits KRAS LADC growth in vivo