Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding

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• 作者：Casper C. Hoogenraad¹ ; ^{c.hoogenraad@uu.nl" class="auth_mail" title="E-mail the corresponding author} ; Anna Akhmanova¹ ; ^{a.akhmanova@uu.nl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：microtubule ; dynein ; kinesin ; adaptor ; vesicle transport ; bicaudal ; mRNA transport
• 刊名：Trends in Cell Biology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：26
• 期：5
• 页码：327-340
• 全文大小：2378 K

文摘

Transport of different intracellular cargoes along cytoskeleton filaments is essential for the morphogenesis and function of a broad variety of eukaryotic cells. Intracellular transport is mediated by cytoskeletal motors including myosin, kinesin, and dynein, which are typically linked to various cargoes by adaptor proteins. Recent studies suggest that adaptor proteins can also act as essential transport cofactors, which control motor activity and coordination. Characterization of the evolutionary conserved Bicaudal D (BICD) family of dynein adaptor proteins has provided important insights into the fundamental mechanisms governing cargo trafficking. This review highlights the advances in the current understanding of how BICD adaptors regulate microtubule-based transport and how they contribute to developmental processes and human disease.