Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation
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- 作者：Hyun Min Kim ; Jeong Woo Han ; Jefferson Y. Chan ; jchan@uci.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nrf1 ; Nuclear Factor Erythroid-2 Related Factor 1 ; CNC ; cap &lsquo ; n&rsquo ; collar ; bZIP ; basic leucine zipper ; Maf ; musculoaponeurotic fibrosarcoma oncogene ; ARE ; antioxidant response element ; EpRE ; electrophile responsive element ; C/EBP-β ; CCAAT Enhancer-binding protein ; ROS ; reactive oxygen species ; NQO1 ; NAD(P)H ; quinone oxioreductase 1 ; GSH ; glutathione ; GST ; glutathione-S-transferase ; Gpx ; glutathione peroxidase ; Hmox1 ; heme-oxygenase 1 ; Fth ; ferritin heavy chain ; Psm ; proteasome ; ERAD ; ER
- 刊名：Gene
- 出版年：2016
- 出版时间：10 June 2016
- 年：2016
- 卷：584
- 期：1
- 页码：17-25
- 全文大小：544 K
文摘
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Nrf1is a CNC-bZIP transcription factor.
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Nrf1 regulates expression of genes involved in cellular stress response.
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Nrf1 is critical for maintaining proteostasis.
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Nrf1 expression is controlled by its protein stability.
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Knockout mouse studies suggest the importance of Nrf1 in cancer, neurodegenerative and metabolic disorders.