Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy
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- 作者：Rohan Jagirdar1 ; Meinrad Drexel1 ; Elke Kirchmair ; Ramon O. Tasan ; Gü ; nther Sperk ; guenther.sperk@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; alpha-amino-3-hydroxy-5-methyl-isoxazole-propionic acid ; GluA2 ; AMPA receptor subunit 2 ; KA ; kainic acid ; HDAC ; histone deacetylase ; TLE ; temporal lobe epilepsy ; BDNF ; brain-derived neurotrophic factor
- 刊名：Experimental Neurology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：273
- 期：Complete
- 页码：92-104
- 全文大小：2336 K
文摘
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Pronounced dynamic changes of class I and IV HDACs in the hippocampus during epileptogenesis
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Decreased expression of HDACs during the status epilepticus coincides with time window of increased protein expression
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Increased HDAC expression during recovery from status epilepticus coincides with the phase of epileptogenesis