A study of epilepsy according to the age at onset and monitored for 3 years in a regional reference paediatric neurology unit

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• 作者：Laura Ochoa-Gó ; mez^a ; Javier Ló ; pez-Pisó ; n^a ; ^{jlopezpi@salud.aragon.es} ; Carlos Lapresta Moros^b ; Cristina Fuertes Rodrigo^a ; Ruth Fernando Martí ; nez^a ; Pilar Samper-Villagrasa^c ; Lorena Monge-Galindo^a ; José ; Luis Pe&ntilde ; a-Segura^a ; Marí ; a Concepció ; n Garcí ; a-Jimé ; nez^d
• 关键词：Epilepsy ; Cryptogenic epilepsy ; Idiopathic epilepsy ; Symptomatic epilepsy ; Refractory epilepsy ; Childhood ; Epileptic syndrome
• 刊名：Anales de Pediatría (English Edition)
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：86
• 期：1
• 页码：11-19
• 全文大小：581 K
• 卷排序：86

文摘

A study of epilepsy, according to the age at onset of the crisis and its causes, monitored by a Paediatric Neurology Unit over a period of three years.Patients and methodsHistorical cohorts study was conducted by reviewing the Paediatric Neurology medical records database of epileptic children followed-up from 1 January 2008 to 31 December 2010.ResultsA total of 4595 children were attended during the study period. The diagnosis of epilepsy was established in 605 (13.17%): 277 (45.79%) symptomatic, 156 (25.79%) idiopathic, and 172 (28.43%) with cryptogenic epilepsy. Absence epilepsy and benign childhood epilepsy with centro-temporal spikes are the idiopathic epileptic syndromes most prevalent, and the most prevalent symptomatic epilepsies are prenatal encephalopathies. More than one-quarter (26.12%) of epilepsies began in the first year of life, and 67.72% were symptomatic. Refractory epilepsy was observed in 25.29%, 42.46% with cognitive impairment, 26.45% with motor involvement, and 9.92% with an autism spectrum disorder, being more frequent at an earlier age of onset.ConclusionsThe absence of a universally accepted classification of epileptic syndromes makes tasks like this difficult, starting with the terminology. A useful classification would be aetiological, with two groups: a large group with established aetiology, or very likely genetic syndromes, and another with no established cause. The age of onset of epilepsy in each aetiological group helps in the prognosis, which is worsened by refractoriness and associated neurodevelopmental disorders, and are generally worse at an earlier onset and in certain aetiologies.