AUY954, a selective S1P₁ modulator, prevents experimental autoimmune neuritis

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• 作者：Zhi-Yuan Zhang ; Zhiren Zhang ; Caroline Zug ; Barbara Nuesslein-Hildesheim ; David Leppert ; Hermann J. Schluesener
• 关键词：Experimental autoimmune neuritis ; Inflammatory demyelinating polyradiculoneuropathy ; AUY954 ; Sphingosine-1-phosphate receptor 1 ; Lymphocytes ; Macrophages
• 刊名：Journal of Neuroimmunology
• 出版年：2009
• 出版时间：30 November 2009
• 年：2009
• 卷：216
• 期：1-2
• 页码：59-65
• 全文大小：511 K

文摘

Experimental autoimmune neuritis (EAN) is a T cell-mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system and an animal model of human inflammatory demyelinating polyradiculoneuropathy. AUY954, which targets selectively the sphingosine-1-phosphate receptor 1 (S1P₁), is known to sequester lymphocytes into secondary lymphoid tissues. In EAN rats, AUY954 greatly prevented paraparesis if administrated from the day of immunization. T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic nerves of EAN rats were significantly decreased by AUY954 treatment. Therefore, S1P₁ modulation might be a potential treatment option for inflammatory neuropathies.