Effects of beta-hydroxybutyrate on brain vascular permeability in rats with traumatic brain injury
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- 作者：Nurcan Orhana ; Canan Ugur Yilmazb ; f ; Oguzhan Ekizogluc ; Bulent Ahishalid ; Mutlu Kucukb ; Nadir Aricanc ; Imdat Elmasc ; Candan Gü ; rsese ; Mehmet Kayag ; mehmetkaya@ku.edu.tr" class="auth_mail" title="E-mail the corresponding author ; mkaya942@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Traumatic brain injury ; Beta-hydroxybutyrate ; Blood&ndash ; brain barrier ; Horseradish peroxidase ; Occludin ; Glucose transporter-1
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：1631
- 期：Complete
- 页码：113-126
- 全文大小：3314 K
文摘
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We induced experimental traumatic brain injury (TBI) in rats.
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We treated animals with beta-hydroxybutyrate (BHB) after TBI.
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Blood–brain barrier (BBB) permeability increased after TBI.
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BHB increased blood–brain barrier permeability in intact rats.
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BHB did not prevent the transport of Evans blue and horseradish peroxidase to brain.