Polyethyleneimine modified poly(Hyaluronic acid) particles with controllable antimicrobial and anticancer effects

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• 作者：Nurettin Sahiner^a ; ^b ; ^{sahiner71@gmail.com} ; Selin Sagbas^a ; Mehtap Sahiner^c ; Ramesh S. Ayyala^d
• 关键词：Hyaluronic acid microgel/nanogel ; PEI-modified HA particles ; Antimicrobial HA particles ; Biocompatible p(HA)-PEI particles ; Cancer treatment
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：159
• 期：Complete
• 页码：29-38
• 全文大小：2126 K
• 卷排序：159

文摘

Hyaluronic acid (HA) microgels modification with polyethylene imine (PEI) is accomplished. P(HA)-PEI possess strong antibacterial effects against E. coli, S. aureus, and B. subtilis. P(HA)-PEI microgels are biocompatible for L929 fibroblast cells. P(HA)-PEI particles can inhibit MDA-MB-231 breast, and H1299 cancer cells growth.