A two-step synthetic strategy to obtain a water-soluble derivative of curcumin with improved antioxidant capacity and in vitro cytotoxicity in C6 glioma cells
Novel water-soluble derivative of curcumin with therapeutic potential was synthesized. The two-step synthesis from accessible raw materials was reproducible at all time. The dendronization of curcumin confers an optimal hydrophilic/hydrophobic balance. The novel compound exhibited an increased antioxidant activity compared with curcumin. The new compound is cytotoxic in C6 cells by a different mechanism to curcumin.