Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status

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• 作者：Ji Hye Huh^a ; ¹ ; Kwang Joon Kim^b ; ^c ; ¹ ; Seung Up Kim^d ; ^e ; ^f ; Seung Hwan Han^g ; Kwang-Hyub Han^d ; ^e ; ^f ; Bong-Soo Cha^c ; Choon Hee Chung^a ; Byung-Wan Lee^c ; ^{bwanlee@yuhs.ac} ; ^{bwanlee@hotmail.com}
• 关键词：NAFLD ; nonalcoholic fatty liver disease ; NASH ; non-alcoholic steatohepatitis ; MHNO ; metabolically healthy non-obese ; MUNO ; metabolically unhealthy non-obese ; MHO ; metabolically healthy obese ; MUO ; metabolically unhealthy obese ; DM ; diabetes mellitus ; TE ; transient elastography ; CAP ; controlled attenuation parameter ; LSM ; liver stiffness measurement ; ALT ; alanine aminotransferase ; LDL-C ; lower-density lipoprotein cholesterol ; HDL-C ; high-density lipoprotein-cholesterol ; TG ; triglyceride ; IQR ; int
• 刊名：Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：Complete
• 页码：23-31
• 全文大小：474 K
• 卷排序：66

文摘

The pathogenesis of non-alcoholic fatty liver disease (NAFLD) involves multiple concomitant events induced by obesity and metabolic health condition. This study aimed to assess the risk of NAFLD according to metabolic health and obesity status using transient elastography (TE).Materials and MethodsA total of 2198 asymptomatic adults without chronic liver disease and who underwent a medical health check-up were recruited. Subjects were categorized into four groups according to metabolic health and obesity statuses: metabolically healthy non-obese (MHNO); metabolically unhealthy non-obese (MUNO); metabolically healthy obese (MHO); and metabolically unhealthy obese (MUO). Hepatic steatosis was defined as controlled attenuation parameter (CAP) ≥ 238 dB/m, and significant liver fibrosis was defined as liver stiffness measurement (LSM) > 7.0 kPa, as defined by TE.ResultsCompared with MHNO group, the odds ratios (ORs) [95% confidence interval (CI)] for hepatic steatosis were 2.94 [2.32–3.71], 4.62 [3.52–6.07], and 12.02 [9.08–15.92] in the MUNO, MHO, and MUO groups, respectively (P < 0.001) in crude model. Regarding liver fibrosis, there was no significant difference in the ORs in MUNO group (ORs: 0.95 [95% CI, 0.33–2.78], P value = 0.929), whereas there was a significant increase in the ORs in MHO group compared with MHNO group (ORs: 4.32 [95% CI, 1.73–10.76], P = 0.002) in the fully adjusted model.ConclusionOur results show that MHO was associated with both liver steatosis and fibrosis assessed by transient elastography. Our results suggest that a healthy metabolic profile does not protect obese adults from hepatic steatosis or fibrosis, indicating that obesity itself might contribute to liver fibrosis.