Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice
详细信息 查看全文
- 作者：Hina Mira ; Avtar S. Meenaa ; Kamaljit K. Chaudhrya ; Pradeep K. Shuklaa ; Ruchika Gangwara ; Bhargavi Mandaa ; Mythili K. Padalaa ; Le Shenb ; Jerrold R. Turnerb ; Paula Dietricha ; Ioannis Dragatsisa ; RadhaKrishna Raoa ; rrao2@uthsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALT ; alanine aminotransferase ; Cldn ; claudin ; ECL ; enhanced chemiluminescent ; EF ; ethanol fed ; FITC ; fluorescein isothiocyanate ; HRP ; horseradish peroxidase ; LPS ; lipopolysaccharide ; Ocln&minus ; /&minus ; ; occludin gene knockout ; PF ; pair fed ; shRNA ; short hairpin RNA ; TER ; transepithelial electrical resistance ; WT ; wild type ; ZO-1 ; zonula occludens-1
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1860
- 期：4
- 页码：765-774
- 全文大小：2064 K
文摘
- •
Occludin deficiency enhances chronic ethanol-induced increase in mucosal permeability in mouse colon.
- •
Ethanol-induced disruption of apical junctional complexes in colonic epithelium is more severe in occludin deficient mice.
- •
Occludin deficiency promotes ethanol-induced liver damage.
- •
Ethanol-induced fatty liver is more severe in occludin deficient mice.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |