Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming
详细信息 查看全文
- 作者：Jun Chen1 ; 2 ; 3 ; 4 ; Xiaolong Chen3 ; 4 ; Min Li3 ; 4 ; Xiaoyu Liu2 ; Yawei Gao3 ; Xiaochen Kou3 ; Yanhong Zhao3 ; Weisheng Zheng3 ; Xiaobai Zhang3 ; Yi Huo2 ; Chuan Chen3 ; You Wu3 ; Hong Wang3 ; Cizhong Jiang3 ; czjiang@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shaorong Gao3 ; gaoshaorong@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oct4 ; reprogramming ; histone modification ; iPSC
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：14
- 期：6
- 页码：1540-1554
- 全文大小：6050 K
文摘
- •
Oct4 binds to target sites in a hierarchical fashion during reprogramming
- •
Primed epigenetic changes are set for Oct4 binding
- •
Oct4 binds to enhancers in more intricate modes than to promoters
- •
Oct4 regulates gene expression with distinct functional themes at different stages