Wax based floating solid dispersion pellets were developed and optimized.
Low-density matrix pellet cores were prepared with the floating assistant octadecanol and microcrystalline cellulose.
The fourth generation drug/ethyl cellulose dispersion was obtained and layered by single-step technique.
Ethyl cellulose of various viscosities (10cp/45cp/100cp) has different sustained release abilities.
SEM, DSC, XRD and FTIR were applied for physicochemical characterization.