ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

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• 作者：Yu-Wen Alvin Huang¹ ; Bo Zhou¹ ; ² ; Marius Wernig² ; Thomas C. Sü ; dhof¹ ; ³ ; ^{tcs1@stanford.edu}
• 关键词：apolipoprotein E ; ApoE ; Alzheimer&rsquo ; s disease ; MAP kinase signaling ; amyloid precursor protein ; APP ; beta amyloid ; Aβ ; cFos ; CRISPR ; CRISPRi ; dual leucine-zipper kinase ; DLK ; transcription
• 刊名：Cell
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：168
• 期：3
• 页码：427-441.e21
• 全文大小：11244 K
• 卷排序：168

文摘

Human ApoE robustly stimulates APP transcription and Aβ production in human neurons ApoE4 is more potent and ApoE2 less potent than ApoE3 in stimulating Aβ production ApoE activates a non-canonical MAP kinase pathway involving DLK, MKK7, and ERK1/2 ApoE-activated MAP kinases phosphorylate cFos to induce APP and Aβ production