Autoacetylation of NAT10 is critical for its function in rRNA transcription activation

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• 作者：Shiying Cai^a ; Xiaofeng Liu^a ; Chunfeng Zhang^b ; Baocai Xing^c ; Xiaojuan Du^a ; ^{duxiaojuan100@bjmu.edu.cn}
• 关键词：Acetylation ; Autoacetylation ; rRNA transcription ; UBF
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：624-629
• 全文大小：1073 K
• 卷排序：483

文摘

NAT10 undergoes autoacetylation in vivo and in vitro. The autoacetylation site of NAT10 is K426, which is evolutionarily conserved. Autoacetylation of NAT10 is indispensable for its function in activating rRNA transcription.