Early gene activation initiates neuroinflammation prior to VSV neuroinvasion: Impact on antiviral responses and sleep

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• 作者：Richard P. Ciavarra^a ; ^{ciavarrp@evms.edu} ; Patric Lundberg^a ; Mayumi Machida^b ; Marta A. Ambrozewicz^b ; Laurie L Wellman^b ; Kimberly Breving^a ; Christina Steel^a ; ¹ ; Larry D. Sanford^b
• 关键词：REM sleep ; rapid eye movement ; NREM sleep ; non-rapid eye movement sleep ; IFN-I ; type I interferon ; PI ; post infection ; TLRs ; Toll like receptors ; RIG-I ; retinoic acid inducible gene-I ; ICV ; intracerebroventricular ; NLRP3 ; nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) pyrin-containing protein 3 ; OB ; olfactory bulb ; VP ; ventral pons ; DP ; dorsal pons ; Hypo ; hypothalamus ; BF ; basal forebrain ; B6 ; C57Bl/6J ; VSV ; vesicular stomatitis virus ; DRN ; dorsal raphe nucleus ; IPA ; Ingen
• 刊名：Journal of Neuroimmunology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：303
• 期：Complete
• 页码：31-42
• 全文大小：1505 K
• 卷排序：303

文摘

VSV neuroinvasion induced a robust and complex global brain cytokine response with bimodal kinetics. Brain cytokine profiles were regionally restricted and generally unrelated to peripheral responses. A discordance between cytokine mRNA synthesis and translation occurred for CXCL10 and OPN. Temporally regulated Innate signaling activation occurred prior to and coincident with VSV neuroinvasion. Il-1, but not several induced chemokines, replicated VSV-induced REM sleep suppression.