Pb exposure prolongs the time period for postnatal transient uptake of 5-HT by murine LSO neurons

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• 作者：Sunyoung Park^a ; ^b ; Andrew B.C. Nevin^a ; Fernando Cardozo-Pelaez^a ; Diana I. Lurie ; Ph.D.^a ; ^{Diana.lurie@umontana.edu}
• 关键词：Lead acetate ; Serotonin reuptake transporter (SERT) ; Serotonin ; Superior olivary nuclei ; Auditory system ; Development
• 刊名：NeuroToxicology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：57
• 期：Complete
• 页码：258-269
• 全文大小：4347 K
• 卷排序：57

文摘

Developmental Pb exposure prolongs transient expression of 5-HT in postnatal murine LSO neurons. Pb-induced 5-HT expression correlates with expression of SERT on LSO cell bodies. Prolonged expression of 5-HT after Pb exposure leads to decreased synapses in LSO. Decreased LSO synapses might contribute to cognitive deficits linked to Pb exposure.