Disinhibition of the intergeniculate leaflet network in the WAG/Rij rat model of absence epilepsy

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• 作者：Lukasz Chrobok^a ; ^{lukasz.chrobok@uj.edu.pl} ; Katarzyna Palus^a ; ^{k.palus@uj.edu.pl} ; Jagoda Stanislawa Jeczmien-Lazur^a ; ^{jagoda.jeczmien@doctoral.uj.edu.pl} ; Anna Chrzanowska^a ; ^{anna.chrzanowska@student.uj.edu.pl} ; Mariusz Kepczynski^b ; ^{kepczyns@chemia.uj.edu.pl} ; Marian Henryk Lewandowski^a ; ^{marian.lewandowski@uj.edu.pl}
• 关键词：AP-5 ; 2-amino-5-phosphonopentanoic acid ; CNQX ; 6-cyano-7-nitroquinoxaline-2 ; 3-dione ; DLG ; dorsal part of the lateral geniculate complex ; ENK ; enkephalin ; GABA ; γ-amino butyric acid ; GFAP ; glial fibrillary acidic protein ; IA ; A-type potassium current ; IGL ; intergeniculate leaflet ; ISO ; infra-slow oscillations ; IT ; T-type calcium current ; mIPSC ; miniature inhibitory postsynaptic currents ; NPY ; neuropeptide Y ; OPN ; olivary pretectal nucleus ; SCN ; suprachiasmatic nucleus ; sIPSC ; spontaneous inhibito
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：289
• 期：Complete
• 页码：103-116
• 全文大小：2502 K
• 卷排序：289

文摘

IPSC amplitude and sIPSC frequency are lowered in intergeniculate leaflet (IGL) in WAG/Rij rats. Infra-slow oscillatory activity in IGL persists in darkness in absence epilepsy model. Astrogliosis was found in IGLs collected from WAG/Rij rats.