Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood

详细信息    查看全文

• 作者：Ruairi C. Robertson^a ; ^b ; ^c ; ¹ ; Clara Seira Oriach^c ; ^d ; ¹ ; Kiera Murphy^b ; Gerard M. Moloney^e ; John F. Cryan^c ; ^e ; Timothy G. Dinan^c ; ^d ; R. Paul Ross^f ; Catherine Stanton^b ; ^c ; ^d ; ^{Catherine.stanton@teagasc.ie}
• 关键词：PUFA ; polyunsaturated fatty acid ; HPA axis ; hypothalamic-pituitary-adrenal axis ; LPS ; lipopolysaccharide ; ConA ; concanavalin A ; CNS ; central nervous system ; AA ; arachidonic acid ; EPA ; eicosapentaenoic acid ; DHA ; docosahexaenoic acid ; SCFA ; short chain fatty acids ; LCFA ; long chain fatty acid ; FAME ; fatty acid methyl esters ; GC ; gas chromatography ; OTU ; operational taxonomic unit ; PCoA ; principal coordinate analysis ; USV ; isolation-induced ultrasonic vocalization ; FST ; forced swim test ; PND ; post
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：21-37
• 全文大小：2507 K
• 卷排序：59

文摘

Omega-3 deficiency impairs communicative, social and depressive behaviour. Omega-3 supplementation enhances cognition and dampens HPA-axis activation. Omega-3 availability adjacently regulates inflammation and gut microbiota composition. Behaviours associated with varying omega-3 availability may be mediated by microbiota.