K-RAS mutations indicating primary resistance to crizotinib in ALK-rearranged adenocarcinomas of the lung: Report of two cases and review of the literature
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- 作者：Maria Cecilia Mengolia ; cecilia.mengoli@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Fausto Barbierib ; Federica Bertolinib ; Marcello Tiseoc ; Giulio Rossia
- 关键词：EGFR ; epidermal growth factor receptor ; KRAS ; Kirsten rat sarcoma viral oncogene homolog ; ALK ; Anaplastic Lymphoma Kinase ; FISH ; fluorescent in situ hybridization ; IHC ; immunohistochemistry ; NSCLC ; non-small-cell lung cancer
- 刊名：Lung Cancer
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：55-58
- 全文大小：932 K
文摘
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K-RAS and ALK alterations in NSCLC may co-exist.
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K-RAS mutations confer crizotinib resistance to ALK-rearranged NSCLC.
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K-RAS appears a strong negative predictive marker in oncogenic-driven NSCLC.