Precision Optogenetic Tool for Selective Single- and Multiple-Cell Ablation in a Live Animal Model System

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• 作者：Kalpana Makhijani¹ ; ² ; ⁶ ; Tsz-Leung To¹ ; ² ; ⁶ ; Rubé ; n Ruiz-Gonzá ; lez¹ ; ² ; ³ ; Cé ; line Lafaye⁴ ; ⁵ ; Antoine Royant⁴ ; ⁵ ; Xiaokun Shu¹ ; ² ; ⁷ ; ^{xiaokun.shu@ucsf.edu}
• 关键词：cell ablation ; optogenetics ; fluorescent proteins ; photosensitizer ; photoreceptor ; reactive oxyge species ; Drosophila ; neurons ; wing ; developmental biology
• 刊名：Cell Chemical Biology
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：110-119
• 全文大小：2717 K
• 卷排序：24

文摘

An efficient photosensitizer miniSOG2 is engineered using directed evolution miniSOG2 enables precision photoablation of single neurons in live Drosophila miniSOG2 allows optogenetic ablation of cells in wing imaginal disc