Minimal essential region for krüppel-like factor 5 expression and the regulation by specificity protein 3-GC box binding

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• 作者：Nozomi Mihara^a ; ^{leschang@tky.ndu.ac.jp} ; Tadashige Chiba^a ; ^{tchiba@tky.ndu.ac.jp} ; Kosuke Yamaguchi^a ; ^{kyama@tky.ndu.ac.jp} ; Haruka Sudo^a ; ^{sudoh@tky.ndu.ac.jp} ; Hisao Yagishita^b ; ^{h-yagishita@tky.ndu.ac.jp} ; Kazushi Imai^a ; ^{kimai@tky.ndu.ac.jp}
• 关键词：KLF ; Krü ; ppel-like factor ; Sp ; specificity proteins ; MER ; minimal essential region ; PCR ; polymerase chain reaction ; Luc ; luciferase ; siRNA ; short interfering RNA ; RLA ; relative Luc activity ; ChIP ; chromatin immunoprecipitation
• 刊名：Gene
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：601
• 期：Complete
• 页码：36-43
• 全文大小：1110 K
• 卷排序：601

文摘

A 186 bp region is the MER for KLF5 basal expression. A GC box in the MER is a critical element for the expression. Sp3 was predominantly expressed and co-localizes with KLF5 in oral carcinomas. Sp3-GC box binding is essential for KLF5 expression.