1′-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells
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- 作者：Akiko Kojima-Yuasaa ; kojima@life.osaka-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Tomiya Yamamotoa ; Keisuke Yakua ; Shiori Hirotaa ; Shigeo Takenakab ; Kouichi Kawabec ; Isao Matsui-Yuasaa
- 关键词：Morris water maze test ; Y-maze test ; 1&prime ; -Acetoxychavicol acetate ; Senescence-accelerated mouse prone 8 (SAMP8) ; Metabolite profile ; β-Hydroxybutyric acid
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 September 2016
- 年：2016
- 卷：257
- 期：Complete
- 页码：101-109
- 全文大小：1898 K
文摘
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1′-Acetoxychavicol acetate (ACA) improves short- and long-term memory in SAMP8 mice.
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Serum metabolite profiles were obtained by GC-MS analysis.
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ACA increased the serum β-hydroxybutyric acid and palmitic acid.
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ACA did not occur the histological damage in the CA1 region of the hippocampus.