Metabolome analysis reveals the effect of carbon catabolite control on the poly(γ-glutamic acid) biosynthesis of Bacillus licheniformis ATCC 9945

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Metabolome analysis reveals the effect of carbon catabolite control on the poly(γ-glutamic acid) biosynthesis of Bacillus licheniformis ATCC 9945

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作者：Hitoshi Mitsunagaup>1up>up> ; up>up>hitoshi_mitsunaga@bio.eng.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding authorup> ; Lena Meissnerup>2up>up> ; up>up>Lena.Meissner@avt.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding authorup> ; Thomas Palmenup>2up>up> ; up>up>Thomas.Palmen@avt.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding authorup> ; Takeshi Bambaup>1up>up> ; up>up>3up>up> ; up>up>bamba@bio.eng.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding authorup> ; Jochen B&uuml ; chsup>2up>up> ; up>up>Jochen.Buechs@avt.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding authorup> ; Eiichiro Fukusakiup>1up>up> ; up>up>fukusaki@bio.eng.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding authorup>
关键词：Bacillus licheniformis ATCC 9945 ; Poly(γ-glutamic acid) ; Carbon catabolite control ; Metabolomics ; Ion-pair-liquid chromatography coupled with tandem mass spectrometry
刊名：Journal of Bioscience and Bioengineering
出版年：2016
出版时间：April 2016
年：2016
卷：121
期：4
页码：413-419
全文大小：541 K

文摘

•: This is the first report of metabolome analysis on PGA producing Bacillus licheniformis.
•: This study revealed the carbon catabolite repression mechanism in PGA production.
•: Pulsed addition of citrate and ammonium achieved the highest PGA production.

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