- 作者：Makoto Tomaru ; Hirohisa Takano ; Naomi Osakabe ; Akiko Yasuda ; Ken-ichiro Inoue ; Rie Yanagisawa ; Tsuneto Ohwatari ; Hiroshi Uematsu
- 关键词：Type 2 diabetes mellitus ; Obesity ; Cacao liquor proanthocyanidins ; Hyperglycemia ; Antioxidation
- 刊名：Nutrition
- 出版年：2007
- 出版时间：April 2007
- 年：2007
- 卷：23
- 期：4
- 页码：351-355
- 全文大小：190 K
Effective approaches should be established to prevent the onset of type 2 diabetes mellitus, which has been increasing in developed countries. The present study examined whether dietary supplementation with cacao liquor proanthocyanidins (CLPr) could prevent elevation of blood glucose levels in mice with diabetes mellitus and obesity.
Methods
C57BL/KsJ-db/db (db/db) diabetic obese mice and C57BL/KsJ-db/+m (db/+m) control mice were fed a diet containing 0 % w/w CLPr (0 % CLPr), 0.5 % w/w CLPr (0.5 % CLPr), or 1.0 % w/w CLPr (1.0 % CLPr) from age 3 wk to age 6 wk. Levels of blood glucose were measured at 4 and 5 wk of age. The animals were sacrificed and the levels of blood glucose and fructosamine were measured at 6 wk of age.
Results
The levels of blood glucose and fructosamine were higher in the db/db mice than in the db/+m mice fed a diet containing 0 % , 0.5 % , or 1.0 % CLPr. In the db/+m mice, the levels of blood glucose or fructosamine were not significantly different across animals fed 0 % CLPr, 0.5 % CLPr, and 1.0 % CLPr. In the db/db mice, however, a diet containing 0.5 % or 1.0 % CLPr decreased the levels of blood glucose and fructosamine compared with that containing 0 % CLPr without significant effects on body weights or food consumption.
Conclusion
Dietary supplementation with CLPr can dose-dependently prevent the development of hyperglycemia in diabetic obese mice. The dietary intake of food or drinks produced from cacao beans might be beneficial in preventing the onset of type 2 diabetes mellitus.