Intensity-Based Assessment of Microbubble-Enhanced Ultrasonography: Phase-Related Diagnostic Ability for Cellular Differentiation of Hepatocellular Carcinoma

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• 作者：Takayuki Kondo ; Hitoshi Maruyama ; ^{maru-cib@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Soichiro Kiyono ; Tadashi Sekimoto ; Taro Shimada ; Masanori Takahashi ; Sadahisa Ogasawara ; Eiichiro Suzuki ; Yoshihiko Ooka ; Akinobu Tawada ; Tetsuhiro Chiba ; Fumihiko Kanai ; Osamu Yokosuka
• 关键词：Contrast-enhanced ultrasound ; Hepatocellular carcinoma ; Cellular differentiation
• 刊名：Ultrasound in Medicine & Biology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：41
• 期：12
• 页码：3079-3087
• 全文大小：1034 K

文摘

This prospective study aimed to elucidate the effect of phase-related quantitative parameters of contrast-enhanced ultrasound (CEUS) with perflubutane microbubble agent to assess the cellular differentiation of hepatocellular carcinoma (HCC). Intensity was analyzed in 94 lesions (19.4 ± 4.9 mm, 86 patients), 47 well-differentiated HCCs (wHCCs) and 47 moderately-differentiated HCCs (mHCCs): I_e (early phase) = I_te (tumor) − I_le (liver), I_p (post-vascular phase) = I_tp (tumor) − I_lp (liver), I_ep = I_e − I_p. The area under the receiver operating characteristic curve with the best cutoff value (I_e, 13.2, I_p, −4.5, I_ep, 21.3) for discriminating between wHCC and mHCC was 0.6922 for I_e, 0.7680 for I_p and 0.7925 for I_ep, which indicated a significantly greater ability to differentiate between wHCC and mHCC compared with visual/qualitative assessment (early phase, 0.6170, p = 0.04; post-vascular phase, 0.6702, p = 0.01; both phases, 0.7021, p = 0.04). In conclusion, I_ep was found to have the highest diagnostic ability, suggesting it is a promising parameter for the cellular differentiation of HCCs with CEUS.