Altered neural oscillations and elevated dopamine levels in the reward pathway during alcohol relapse
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- 作者：Ravit Hadara ; Mareike Vogeta ; b ; Valentina Vengelienec ; Jens K. Haumesserd ; Christoph van Riesend ; Yosef Avchalumova ; Rainer Spanagelc ; Christine Wintera ; christine.winter@uniklinikum-dresden.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alcohol use disorder ; Relapse ; Alcohol deprivation effect ; Medial prefrontal cortex ; Nucleus accumbens ; Dopamine ; Local field potentials ; Beta band oscillations
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：131-135
- 全文大小：519 K
文摘
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Altered reward network activity was studied in a DSM-based rat model of AUD.
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Relapse presented with increased dopamine availability in the nucleus accumbens.
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Enhanced dopamine levels went along with reduced synchronous oscillatory activity.
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Altered oscillatory activity presumably relates to dopaminoceptive MSN.
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Reduced β band oscillations may be indicative of a vulnerable state for relapse.
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