The anti-atherogenic effects of eicosapentaenoic and docosahexaenoic acid are dependent on the stage of THP-1 macrophage differentiation
详细信息 查看全文
- 作者：Sheila McCartana ; b ; Lesley A. Powella ; Brian D. Greenb ; Jane McEnenya ; Ann McGintya ; a.mcginty@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：AA ; arachidonic acid ; CS ; cell surface ; CVD ; cardiovascular disease ; DHA ; docosahexaenoic acid ; ECACC ; European Collection of Cell Cultures ; EPA ; eicosapentaenoic acid ; INSIG ; insulin induced gene ; LA ; linoleic acid ; LOX-1 ; lectin-like oxidised LDL receptor-1 ; PBMC ; peripheral blood monocytic cells ; PKC ; protein kinase C ; PMA ; phorbol 12-myristate 13-acetate ; PUFA ; polyunsaturated fatty acid ; SCAP ; SREBP-cleaving activating protein ; SREBP ; sterol regulatory element binding proteins ; TNF-α ; tumor
- 刊名：Journal of Functional Foods
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：19
- 期：part_PB
- 页码：958-969
- 全文大小：2327 K
文摘
- 10">
- •
10">LC n-3 PUFA specific effects on initial stages of atherosclerosis.
- •
15">Investigation of effects on an early and late stage macrophage differentiation model.
- •
Differentiation markers and scavenger receptors are more affected in early stages.
- •
DHA can affect lipoprotein receptor levels in late stage differentiation.
- •
LC n3/n6 PUFA decrease basal cholesterol levels in early stage macrophages.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |