Maternal diabetes and high glucose in vitro trigger Sca1⁺ cardiac progenitor cell apoptosis through FoxO3a

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• 作者：Penghua Yang^a ; ¹ ; Wendy W. Yang^b ; ¹ ; Xi Chen^a ; Sunjay Kaushal^b ; Daoyin Dong^a ; Wei-Bin Shen^a ; ^{wshen@fpi.umaryland.edu}
• 关键词：Sca1+ cardiac progenitor cells ; Maternal diabetes ; Diabetic embryopathy ; Apoptosis ; FoxO3a ; High glucose
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：575-581
• 全文大小：1517 K
• 卷排序：482

文摘

Maternal diabetes and high glucose in vitro induce Sca1+ cardiac progenitor apoptosis. foxo3a gene deletion blocks maternal diabetes-induced Sca1+ cardiac progenitor apoptosis. Constitutively active FoxO3a mimics whereas dominant negative FoxO3a inhibits high glucose-induced apoptosis. FoxO3a mediates the pro-apoptotic effect of diabetes and high glucose on Sca1+ cardiac progenitors.