Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility
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- 作者：Masafumi Sadaa ; Kenoki Ohuchidaa ; b ; kenoki@surg1.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kohei Horiokaa ; Takashi Okumuraa ; Taiki Moriyamaa ; Yoshihiro Miyasakaa ; Takao Ohtsukaa ; Kazuhiro Mizumotoa ; Yoshinao Odac ; Masafumi Nakamuraa
- 关键词：PSC ; pancreatic stellate cell ; ECM ; extracellular matrix ; 3-D ; three-dimensional ; PLOD2 ; procollagen-lysine ; 2-oxoglutarate 5-dioxygenase 2 ; α-SMA ; α-smooth muscle actin ; HIF-1α ; hypoxia-inducible factor-1α ; GFAP ; glial fibrillary acidic protein
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 March 2016
- 年：2016
- 卷：372
- 期：2
- 页码：210-218
- 全文大小：2896 K
文摘
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Pancreatic stellate cells create parallel ECM fiber architecture under hypoxia.
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ECM fibers under hypoxia enhance directionality of cancer cell movement.
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20">Hypoxia-induced PLOD2 regulates topographical organization of ECM fibers.
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25">ECM remodeling by PLOD2 promotes directional migration of pancreatic cancer cells.