VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome
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- 作者：Sarah E. Murphy ; Tim P. Levine ; tim.levine@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：AKAP ; A-kinase anchor protein ; ALS ; Amyotrophic Lateral Sclerosis ; CERT ; ceramide transfer protein ; ER ; endoplasmic reticulum ; ERAD ; ER-associated destruction ; FFAT ; two phenylalanines in an acidic tract ; MSP ; major sperm protein ; ORP ; OSBP-related protein ; OSBP ; oxysterol binding protein ; RdgB ; retinal degeneration type B ; VAMP ; Vesicle-associated membrane protein ; VAP ; VAMP-Associated Protein ; VAPome ; VAP interactome
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1861
- 期：8
- 页码：952-961
- 全文大小：1398 K
文摘
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Proteins that interact with the ER from outside all interact with VAP.
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VAP has a conserved domain with multiple binding sites for different ligands.
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≥ 50% of VAP binders have motifs in the general form of “two phenylalanines in an acidic tract” (FFAT).
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Neurodegeneration is associated with reduced levels of VAP.
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Many myths about VAP pathology result from experiments with over-expression.