Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop

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• 作者：Eva S. Cunha¹ ; Pedro Sfriso² ; ³ ; Adriana L. Rojas¹ ; Adam Hospital² ; ³ ; Modesto Orozco³ ; ⁴ ; Nicola G.A. Abrescia¹ ; ⁵ ; ⁶ ; ^{nabrescia@cicbiogune.es}
• 关键词：receptor structure-function ; tetraspanin CD81 ; virus entry ; X-ray crystallography ; molecular dynamics ; hepatitis C virus
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：53-65
• 全文大小：3798 K
• 卷排序：25

文摘

CD81LEL crystal structures cluster in closed, intermediate, and open conformations CD81LEL crystallographic conformers are visited in molecular dynamics simulations Molecular dynamics simulations show a CD81LEL conformational pH dependence CD81LEL conformational pH dependence is foreseen to have a major role in HCV entry