C-terminal amidation of PACAP-38 and PACAP-27 is dispensable for biological activity at the PAC1 receptor
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- 作者：Andrew C. Emerya ; Ryan A. Alvareza ; Philip Abbouda ; Wenqin Xub ; Craig D. Westoverb ; Maribeth V. Eidenb ; Lee E. Eidena ; eidenl@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：cAMP ; cyclic adenosine 3&prime ; 5&prime ; -monophosphate ; CPE ; carboxypeptidase E/H ; CRE ; cyclic AMP response element ; GPCR ; G protein-coupled receptor ; NPY ; neuropeptide Y ; NS-1 ; Neuroscreen-1 ; PACAP ; pituitary adenylate cyclase-activating polypeptide ; PAC1 ; PACAP type 1 receptor ; PAM ; peptidylglycine alpha-amidating monooxygenase ; PC ; prohormone convertase ; PKA ; protein kinase A ; PTS-6 ; peptide transport system 6 ; VIP ; vasoactive intestinal polypeptide ; VPAC1/2 ; vasoactive intestinal polypeptide
- 刊名：Peptides
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：79
- 期：Complete
- 页码：39-48
- 全文大小：2413 K
文摘
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In vivo PACAP is a C-terminally α-amidated neuropeptide of 27 or 38 residues.
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PACAP does not require α-amidation to activate the rat or human PAC1 receptor.
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Amidation of PACAP is also dispensable for neuroendocrine cell differentiation.