Recombinant proteins of helminths with immunoregulatory properties and their possible therapeutic use

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• 作者：Leonardo Nascimento Santos ^{nsleo.1@gmail.com} ; Luis Gustavo Carvalho Pacheco ^{lgcpacheco@gmail.com} ; Carina Silva Pinheiro ^{carinaspinheiro@yahoo.com.br} ; Neuza Maria Alcantara-Neves ; ^{neuzalcantara@gmail.com}
• 关键词：Expression systems ; Helminthes ; Immunomodulation ; Inflammatory diseases ; Recombinant proteins
• 刊名：Acta Tropica
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：202-211
• 全文大小：1646 K
• 卷排序：166

文摘

The current approaches for identification of helminth proteins with potential immunoregulatory properties. Methodological approaches and expression systems used for production of recombinant helminth immunomodulatory proteins. The performances of recombinant helminth proteins as immunotherapy to treat immune-mediated conditions. Perspective of parasite-derived recombinant molecules as tools for future prophylaxis/immunotherapy of inflammatory diseases.