Design and optimization of pulsed Chemical Exchange Saturation Transfer MRI using a multiobjective genetic algorithm

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• 作者：Eriko S. Yoshimaru ; Edward A. Randtke ; Mark D. Pagel ; Julio Cá ; rdenas-Rodrí ; guez ; ^{cardenaj@email.arizona.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chemical Exchange Saturation Transfer ; Pulsed CEST MRI ; Shaped pulses ; Pulse design ; Iopromide ; Salicylic acid ; Genetic algorithm
• 刊名：Journal of Magnetic Resonance
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：263
• 期：Complete
• 页码：184-192
• 全文大小：1590 K

文摘

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d="p0005">Pulsed CEST MRI experimental parameters and pulse shapes were optimized using a genetic algorithm (GA).

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d="p0010">GA-optimized saturation shaped pulses showed an increase in % CEST effect compared to pre-saturation using Gaussian-shaped saturation pulses.

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d="p0015">Simulations were validated by experiments using ammonium chloride, iopromide, and salicylic acid tested in a 3 T clinical MRI scanner.

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