Chemopreventive activity of crude hydroxsymatairesinol (HMR) extract in Apc^Min mice

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• 作者：Oikarinen ; Seija I. ; Pajari ; Anne-Maria ; Mutanen ; Marja
• 关键词：Hydroxymatairesinol ; Rye ; Intestinal polyps ; Apc^Min mice
• 刊名：Cancer Letters
• 出版年：2000
• 出版时间：December 20, 2000
• 年：2000
• 卷：161
• 期：2
• 页码：253-258
• 全文大小：117 K

文摘

We studied the effects of a lignan, hydroxymatairesinol (HMR), and rye bran on intestinal tumor development in adenomatous polyposis colimultiple intestinal neoplasia (Apc)^Min mice. HMR showed a strong chemopreventive effect in this animal model. The mean number of adenomas in the small intestine was significantly lower (26.6±11.0, P<0.05) in mice fed the inulin and HMR when compared with the inulin and inulin/rye bran fed mice (39.6±8.9 and 36.0±7.4, respectively). HMR resulted in normalization of β-catenin levels in adenoma tissue, indicating that HMR mediates its chemopreventive effect through the Apc-β-catenin pathway. In the cytosolic fraction, β-catenin level in adenoma tissue was significantly elevated (P