Synthesis, electronic structure and molecular docking of new organometallic palladium (II) complexes with intercalator ligands: The influence of bridged ligands on enhanced DNA/serum protein binding and in vitro antitumoral activity

详细信息    查看全文

• 作者：Kazem Karami^a ; ^{karami@cc.iut.ac.ir} ; Zohreh Mehri Lighvan^a ; Maryam Dehdashti Jahromi^a ; Janusz Lipkowski^b ; Amir Abbas Momtazi-borojeni^c
• 关键词：Palladacycle ; DNA-binding ; BSA binding ; Site markers
• 刊名：Journal of Organometallic Chemistry
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：827
• 期：Complete
• 页码：1-14
• 全文大小：3608 K
• 卷排序：827

文摘

Synthesis of novel palladium-based active biologically complexes containing intercalator lignads. Study of the ability of the complexes to interact with DNA via intercalation mechanism. The molecular docking indicates high binding affinity between DNA and BSA with Pd complexes.