Malony-CoA inhibits the S113L variant of carnitine-palmitoyltransferase II
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- 作者：Leila Motlagha ; leila.motlagh@medizin.uni-halle.de" class="auth_mail" title="E-mail the corresponding author ; Ralph Golbikb ; Wolfgang Sipplc ; Stephan Zierza
- 关键词：CoA ; coenzyme A ; CPT I ; carnitine palmitoyltransferase I ; CPT II ; carnitine palmitoyltransferase II ; hCPT2 ; gene coding for human muscle carnitine palmitoyltransferase II ; MD ; molecular dynamics
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1861
- 期：1
- 页码：34-40
- 全文大小：762 K
文摘
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CPT II and not only CPT I can be inhibited by malonyl-CoA.
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The inhibition is more pronounced for the variant S113L of this enzyme.
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By docking studies malonyl-CoA could be shown to bind at two sites of the enzyme.